A Crack in Creation

The New Power to Control Evolution

Author: Jennifer Doudna,Samuel Sternberg

Publisher: Random House

ISBN: 1473524199

Category: Science

Page: 304

View: 8228

Jennifer Doudna, the world-famous scientist behind CRISPR, ‘one of the most monumental discoveries in biology’ (New York Times), explains its discovery, describes its power to reshape the future of all life and warns of its use. 'Urgent, riveting and endlessly fascinating, this book is destined to become an instant classic. Read it if you want to understand our biological future' Siddhartha Mukherjee 'In this wonderful book ... Doudna’s and Sternberg’s simple but compelling exploration of this hugely important subject offers and excellent overview of this startling and unprecedented discovery' Literary Review A handful of discoveries have changed the course of human history. This book is about the most recent and potentially the most powerful and dangerous of them all. It is an invention that allows us to rewrite the genetic code that shapes and controls all living beings with astonishing accuracy and ease. Thanks to it, the dreams of genetic manipulation have become a stark reality: the power to cure disease and alleviate suffering, to create new sources of food and energy, as well as to re-design any species, including humans, for our own ends. Jennifer Doudna is the co-inventor of this technology - known as CRISPR - and a scientist of worldwide renown. Writing with fellow researcher Samuel Sternberg, here she provides the definitive account of her discovery, explaining how this wondrous invention works and what it is capable of. She also asks us to consider what our new-found power means: how do we enjoy its unprecedented benefits while avoiding its equally unprecedented dangers? The future of humankind – and of all life on Earth – is at stake. This book is an essential guide to the path that now lies ahead. 'A scientific thriller and a gripping read by a brilliant scientist' Venki Ramakrishnan

A Crack in Creation

Gene Editing and the Unthinkable Power to Control Evolution

Author: Jennifer A. Doudna,Samuel H. Sternberg

Publisher: Houghton Mifflin

ISBN: 9780544716940

Category: MEDICAL

Page: 281

View: 6801

Two Berkeley scientists explore the potential of a revolutionary genetics technology capable of easily and affordably manipulating DNA in human embryos to prevent specific diseases, addressing key concerns about related ethical and societal repercussions.

Modern Prometheus

Author: Jim Kozubek

Publisher: Cambridge University Press

ISBN: 1108454623

Category: Law

Page: 478

View: 8189

This book tells the dramatic story of Crispr and the potential impact of this gene-editing technology.

Redesigning Life

How Genome Editing Will Transform the World

Author: John Parrington

Publisher: Oxford University Press

ISBN: 0198766823

Category: Science

Page: 320

View: 4623

Since the birth of civilisation, human beings have manipulated other life-forms. We have selectively bred plants and animals for thousands of years to maximize agricultural production and cater to our tastes in pets. The observation of the creation of artificial animal and plant variants was a key stimulant for Charles Darwin's theory of evolution. The ability to directly engineer the genomes of organisms first became possible in the 1970s, when the gene for human insulin was introduced into bacteria to produce this protein for diabetics. At the same time, mice were modified to produce human growth hormone, and grew huge as a result. But these were only our first tottering steps into the possibilities of genetic engineering. In the past few years, the pace of progress has accelerated enormously. We can now cut and paste genes using molecular scissors with astonishing ease, and the new technology of genome editing can be applied to practically any species of plants or animals. 'Mutation chain reaction' can be used to alter the genes of a population of pests, such as flies; as the modified creatures breed, the mutation is spread through the population, so that within a few generations the organism is almost completely altered. At the same time, scientists are also beginning to synthesize new organisms from scratch. These new technologies hold much promise for improving lives. Genome editing has already been used clinically to treat AIDS patients, by genetically modifying their white blood cells to be resistant to HIV. In agriculture, genome editing could be used to engineer species with increased food output, and the ability to thrive in challenging climates. New bacterial forms may be used to generate energy. But these powerful new techniques also raise important ethical dilemmas and potential dangers, pressing issues that are already upon us given the speed of scientific developments. To what extent should parents be able to manipulate the genetics of their offspring - and would designer babies be limited to the rich? Can we effectively weigh up the risks from introducing synthetic lifeforms into complex ecosystems? John Parrington explains the nature and possibilities of these new scientific developments, which could usher in a brave, new world. We must rapidly come to understand its implications if we are to direct its huge potential to the good of humanity and the planet.

Genome Editing and Engineering

From TALENs, ZFNs and CRISPRs to Molecular Surgery

Author: Krishnarao Appasani

Publisher: Cambridge University Press

ISBN: 1107170370

Category: Science

Page: 586

View: 5360

A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.

A Conviction in Question

The First Trial at the International Criminal Court

Author: Jim Freedman

Publisher: University of Toronto Press

ISBN: 1487502893

Category: Law

Page: 240

View: 3877

A Conviction in Question follows the foundational and controversial trial of Thomas Lubanga Dyilo, a murderer whose trial is paramount in tracing the rapid evolution of international law.

A Crack in Creation

Gene Editing and the Unthinkable Power to Control Evolution

Author: Jennifer A. Doudna,Samuel H. Sternberg

Publisher: Mariner Books

ISBN: 9781328915368

Category: CRISPR (Genetics)

Page: 304

View: 5177

A trailblazing biologist grapples with her role in the biggest scientific discovery of our era: a cheap, easy way of rewriting genetic code, with nearly limitless promise and peril.

The Age of Genomes

Tales from the Front Lines of Genetic Medicine

Author: Steven Monroe Lipkin,Jon Luoma

Publisher: Beacon Press

ISBN: 0807074578

Category: Genetic disorders

Page: 256

View: 4250

"A leading geneticist explores what promises to be one of the most transformative advances in health and medicine in history. Almost every week, another exciting headline appears about new advances in the field of genetics. Genetic testing is experiencing the exponential growth once seen with the Internet, and the plummeting cost of DNA sequencing makes it increasingly accessible for individuals and families. Dr. Steven M. Lipkin suggests that today's genomics is like the last century's nuclear physics: a powerful tool for good if used correctly, but potentially dangerous in the wrong hands. DNA testing is promising in treating serious disease, but Beijing Genomics, one of the world's largest genomics centers, is quietly developing gene tests to predict intelligence and athletic prowess in prenatal embryo selection. DNA testing could also lead to unnecessary procedures and significantly higher health-care costs. And all too often, sequencing errors diagnose patients with debilitating and fatal genetic diseases.The Genome Generation immerses readers in stories of real patients on the genomics frontier and explores the transformative potential and dangerous risks of genetic technology. It will inform anxious parents increasingly bombarded by offers of costly new prenatal testing products, and demonstrate how genetic technology, when deployed properly, can prevent or treat genetic disorders such as neurological diseases or cancer. Lipkin explains the science in depth, but in terms a layperson can follow"--Provided by publisher.

The Epigenetics Revolution

How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance

Author: Nessa Carey

Publisher: Columbia University Press

ISBN: 0231161174

Category: Science

Page: 352

View: 2744

Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism’s genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the field’s arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.

Life at the Speed of Light

From the Double Helix to the Dawn of Digital Life

Author: J. Craig Venter

Publisher: Penguin

ISBN: 0143125907

Category: Science

Page: 224

View: 4871

The author of A Life Decoded explains how his team's achievement with sequencing the human genome has launched an important age of biological research, revealing a growing potential for enabling humans to adapt and evolve for long-term survival and environmental improvement.



Author: Wolfgang Hunter,Anna Hasselbring

Publisher: AuthorHouse

ISBN: 1546237151

Category: Fiction

Page: 278

View: 9368

Brilliant scientists, maniacal Russians, global leaders and paranoid Mennonites populate this prophetic thriller. First discovered only a few years ago, CRISPR could be the answer to mankinds prayers or the cause of civilizations demise. It could cure cancer or kill every human on the planet. CRISPR is unregulated, dirt cheap, and available to anyone with an Internet account and a credit card. This novel will enlighten you, and scare you, like nothing you have ever read.

The New Microbiology

From Microbiomes to CRISPR

Author: Pascale Cossart

Publisher: N.A

ISBN: 9781683670100

Category: Medical

Page: 200

View: 8711

In The New Microbiology, Pascale Cossart tells a splendid story about the revolution in microbiology, especially in bacteriology.

Drawing the Map of Life

Inside the Human Genome Project

Author: Victor K. McElheny

Publisher: ReadHowYouWant.com

ISBN: 1458760103


Page: 660

View: 3783

Drawing the Map of Life is the dramatic story of the Human Genome Project from its origins, through the race to order the 3 billion subunits of DNA, to the surprises emerging as scientists seek to exploit the molecule of heredity. It's the first account to deal in depth with the intellectual roots of the project, the motivations that drove it, and the hype that often masked genuine triumphs. Distinguished science journalist Victor McElheny offers vivid, insightful profiles of key people, such as David Botstein, Eric Lander, Francis Collins, James Watson, Michael Hunkapiller, and Craig Venter. McElheny also shows that the Human Genome Project is a striking example of how new techniques (such as restriction enzymes and sequencing methods) often arrive first, shaping the questions scientists then ask. Drawing on years of original interviews and reporting in the inner circles of biological science, Drawing the Map of Life is the definitive, up-to-date story of today's greatest scientific quest. No one who wishes to understand genome mapping and how it is transforming our lives can afford to miss this book.


Author: University Jennifer Doudna,Prashant Mali

Publisher: N.A

ISBN: 9781621821304

Category: RNA

Page: 192

View: 5695

The development of CRISPR-Cas technology is revolutionizing biology. Based on machinery bacteria use to target foreign nucleic acids, these powerful techniques allow investigators to edit nucleic acids and modulate gene expression more rapidly and accurately than ever before. Featuring contributions from leading figures in the CRISPR-Cas field, this laboratory manual presents a state-of-the-art guide to the technology. It includes step-by-step protocols for applying CRISPR-Cas-based techniques in various systems, including yeast, zebrafish, Drosophila, mice, and cultured cells (e.g., human pluripotent stem cells). The contributors cover web-based tools and approaches for designing guide RNAs that precisely target genes of interest, methods for preparing and delivering CRISPR-Cas reagents into cells, and ways to screen for cells that harbor the desired genetic changes. Strategies for optimizing CRISPR-Cas in each system--especially for minimizing off-target effects--are also provided. Authors also describe other applications of the CRISPR-Cas system, including its use for regulating genome activation and repression, and discuss the development of next-generation CRISPR-Cas tools. The book is thus an essential laboratory resource for all cell, molecular, and developmental biologists, as well as biochemists, geneticists, and all who seek to expand their biotechnology toolkits.

Summary & Study Guide - A Crack in Creation

Gene Editing and the Unthinkable Power to Control Evolution

Author: Lee Tang

Publisher: LMT Press via PublishDrive

ISBN: 0995943168

Category: Science

Page: 88

View: 2034

The Power and Peril of Gene Editing CRISPR/Cas9 Technology The must-read summary of “A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution” by Jennifer A. Doudna and Samuel H. Sternberg. This complete summary of Jennifer Doudna and Samuel Sternberg’s book tells the story of CRISPR and “gene-editing.” CRISPR is a cutting-edge gene-editing technology that mimics what happens naturally in bacteria. It enables scientists to “play god” with plant or animal DNA, with unlimited power and peril. The technology of gene editing is the most important advance in our era. The possibility of forever altering the genetic composition of humankind is frightening. Yet we can’t overlook the opportunities that may lead to inventions for cures of HIV, debilitating genetic diseases, and cancers, and end food shortages. The book will demystify this exciting area of science and inspire you to seek answers to tough moral and ethical questions on the use of this technology. Read this summary and get involved in the debate on the moral and ethical issues on the use of this technology. This guide includes: * Book Summary—The summary helps you understand the key ideas and recommendations. * Online Videos—on-demand replay of public lectures, and seminars on the topics covered in the chapter. Value-added of this guide: * Save time * Understand key concepts * Expand your knowledge


How Synthetic Biology Will Reinvent Nature and Ourselves

Author: George M. Church,Ed Regis

Publisher: Basic Books

ISBN: 0465038654

Category: Science

Page: 304

View: 6638

“Bold and provocative… Regenesis tells of recent advances that may soon yield endless supplies of renewable energy, increased longevity and the return of long-extinct species.”—New Scientist In Regenesis, Harvard biologist George Church and science writer Ed Regis explore the possibilities—and perils—of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies—far from the out-of-control nightmare depicted in science fiction—have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.

The Consciousness Instinct

Unraveling the Mystery of How the Brain Makes the Mind

Author: Michael S. Gazzaniga

Publisher: Farrar, Straus and Giroux

ISBN: 0374128766

Category: Psychology

Page: 288

View: 4372

“The father of cognitive neuroscience” illuminates the past, present, and future of the mind-brain problem How do neurons turn into minds? How does physical “stuff”—atoms, molecules, chemicals, and cells—create the vivid and various worlds inside our heads? The problem of consciousness has gnawed at us for millennia. In the last century there have been massive breakthroughs that have rewritten the science of the brain, and yet the puzzles faced by the ancient Greeks are still present. In The Consciousness Instinct, the neuroscience pioneer Michael S. Gazzaniga puts the latest research in conversation with the history of human thinking about the mind, giving a big-picture view of what science has revealed about consciousness. The idea of the brain as a machine, first proposed centuries ago, has led to assumptions about the relationship between mind and brain that dog scientists and philosophers to this day. Gazzaniga asserts that this model has it backward—brains make machines, but they cannot be reduced to one. New research suggests the brain is actually a confederation of independent modules working together. Understanding how consciousness could emanate from such an organization will help define the future of brain science and artificial intelligence, and close the gap between brain and mind. Captivating and accessible, with insights drawn from a lifetime at the forefront of the field, The Consciousness Instinct sets the course for the neuroscience of tomorrow.

Cracking the Code

Author: Leah Kaminsky,Stephen Damiani,Sally Damiani

Publisher: Random House Australia

ISBN: 0857984667

Category: Genetic disorders in children

Page: 320

View: 1910

A family doctor shares a mother and father's determination to save their son. This story of a father's search to find a diagnosis, and ultimately a cure, for his son's mystery disease is an inspiration that has set the world of genetic medicine and research abuzz with the possibilities for the future. After Cracking the Code screened on "Australian Story," Stephen Damiani and his extraordinary ordinary family have been inundated with messages of support for Mission Massimo. Stephen has a background in construction economics and risk management. He teamed with geneticist Ryan Taft to map his family's genome in an attempt to discover the cause of his son's illness, and in the process developed a diagnostic tool that will revolutionize diagnoses and treatments of diseases as complex and rare as Massimo's leukodystrophy to widespread diseases such as diabetes and cardiovascular disease. Previously, trying to find a specific gene mutation that might be responsible for a disease was a million times harder than finding a needle in a haystack. Stephen's suggestion that Ryan align the genomes, or DNA blueprints, of himself, his wife Sally as well as Massimo, to find any unique variations and thereby create a smaller haystack was previously untried. Stephen convinced Massimo's neurologist, Dr. Rick Leventer at Melbourne's RCH, that it was just a case of technology, statistics, data, and money, but that it could be done. Once Taft was able to locate and isolate the specific genetic mutation of Massimo's DARS gene, the hunt was on to find other children with the same genetic mutation so that the diagnoses could be confirmed. With the help of Adeline Vanderver at the Washington DC-based Centre for Genetic Medicine and her Myelin Disorders Program, they were able to locate several other children with the DARS mutation and have now moved on to the next phase of Mission Massimo, finding a cure. Cracking the Code is simultaneously a wonderful family memoir and the story of some mind-blowing discoveries in medicine.


The Story of the Genetic Revolution

Author: James D. Watson,Andrew James Berry,Kevin Davies

Publisher: Knopf

ISBN: 0385351186

Category: Medical

Page: 487

View: 7528

Updated edition of: DNA: the secret of life.