Medicinal Natural Products

A Biosynthetic Approach

Author: Paul M. Dewick

Publisher: John Wiley & Sons

ISBN: 1119964571

Category: Science

Page: 550

View: 6293

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Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine. There have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions: a comprehensive treatment of plant, microbial, and animal natural products in one volume extensive use of chemical schemes with annotated mechanistic explanations cross-referencing to emphasize links and similarities boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of action Medicinal Natural Products: A Biosynthetic Approach, Third Edition, is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry.

Medicinal Natural Products

A Biosynthetic Approach

Author: Paul M. Dewick

Publisher: John Wiley & Sons

ISBN: 9780471496410

Category: Medical

Page: 507

View: 5161

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Medicinal Natural Products, Second Edition is a comprehensive guide providing information on all classes of natural products in medicine. It builds upon fundamental chemical principles and demonstrates a unique integration of plant, microbial and animal natural products in one volume. The text guides the reader through a wealth of diverse natural metabolites used in medicine with sources, production methods, use as drugs and modes of action all extensively covered. Taking a chemistry based approach it combines traditional pharmacognosy with medicinal chemistry. The structure is user-friendly and includes the acclaimed grey boxes on groups of products and detailed mechanistic explanations. * Adopts a novel biosynthetic theme rather than a traditional descriptive approach * Includes extensive further reading at the end of the chapter * Thoroughly revised and updated to incorporate comprehensive coverage of plant, microbial and animal products * Includes the latest developments in the field * New material on genetic manipulation of biosynthetic pathways and non-mevalonate pathway to terpanoids * User-friendly format including extensive use of chemical schemes with annotated mechanistic explanations

Medicinal Natural Products

A Biosynthetic Approach

Author: Paul M. Dewick

Publisher: John Wiley and Sons

ISBN: 0470742798

Category: Medical

Page: 550

View: 2980

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Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine. There have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions: a comprehensive treatment of plant, microbial, and animal natural products in one volume extensive use of chemical schemes with annotated mechanistic explanations cross-referencing to emphasize links and similarities boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of action Medicinal Natural Products: A Biosynthetic Approach, Third Edition, is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry.

Essentials of Organic Chemistry

For Students of Pharmacy, Medicinal Chemistry and Biological Chemistry

Author: Paul M. Dewick

Publisher: John Wiley & Sons

ISBN: 1118681967

Category: Science

Page: 704

View: 8370

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Essentials of Organic Chemistry is an accessible introduction to the subject for students of Pharmacy, Medicinal Chemistry and Biological Chemistry. Designed to provide a thorough grounding in fundamental chemical principles, the book focuses on key elements of organic chemistry and carefully chosen material is illustrated with the extensive use of pharmaceutical and biochemical examples. In order to establish links and similarities the book places prominence on principles and deductive reasoning with cross-referencing. This informal text also places the main emphasis on understanding and predicting reactivity rather than synthetic methodology as well as utilising a mechanism based layout and featuring annotated schemes to reduce the need for textual explanations. * tailored specifically to the needs of students of Pharmacy Medical Chemistry and Biological Chemistry * numerous pharmaceutical and biochemical examples * mechanism based layout * focus on principles and deductive reasoning This will be an invaluable reference for students of Pharmacy Medicinal and Biological Chemistry.

The Shikimate Pathway

Biosynthesis of Natural Products Series

Author: Edwin Haslam

Publisher: Elsevier

ISBN: 1483161188

Category: Science

Page: 326

View: 395

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The Shikimate Pathway gives a bird's eye view of the shikimate pathway and its implications for the life of a range of organisms. Topics covered in this book include the chemistry of intermediates in the shikimate pathway; biosynthesis of aromatic amino acids in this pathway; its metabolites; and its role in higher plants. This book is comprised of six chapters and begins by introducing the reader to shikimic acid, a natural product derived from the plant Illicium religiosum, along with the mechanistic and stereochemical aspects of the reactions of the shikimate pathway. The biosynthesis of aromatic amino acids from chorismate is also described, and then the discussion turns to the chemical properties and the detailed stereochemistry of intermediates and enzymes in the shikimate pathway. The next chapter examines the biosynthesis of isoprenoid quinones involved in electron transport and the folic acid group of co-enzymes in the shikimate pathway. The metabolism of the aromatic amino acids in microorganisms and higher organisms is considered, along with the biosynthesis and physiological functions of phenylpropanoid compounds and their derivatives in the shikimate pathway in higher plants. This book will be of general value to practitioners in the many and varied areas of biochemical research associated with metabolism.

Natural Product Biosynthesis

Author: Christopher T Walsh,Yi Tang

Publisher: Royal Society of Chemistry

ISBN: 1788011317

Category: Science

Page: 766

View: 4781

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Authored by leading experts in the enzymology of natural product biosynthesis, this textbook provides a thorough description of the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era. Although some 500-600,000 natural products have been isolated and characterized over the past two centuries, there may be a 10-fold greater inventory awaiting immediate exploration based on biosynthetic gene cluster predictions. The approach of this book is to codify the chemical logic that underlies each natural product structural class as they are assembled from building blocks of primary metabolism. This text will serve as a reference point for chemists of every subdiscipline, including synthetic organic chemists and medicinal chemists. It will also be valuable to bioinformatic and computational biologists, to pharmacognocists and chemical ecologists, to bioengineers and synthetic biologists.

Fundamentals of Pharmacognosy and Phytotherapy E-Book

Author: Michael Heinrich,Joanne Barnes,Simon Gibbons,Elizabeth M. Williamson

Publisher: Elsevier Health Sciences

ISBN: 0702052310

Category: Medical

Page: 336

View: 1661

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‘A new classic’ in a new edition! Fully revised and updated throughout New sections on antimicrobials From journal reviews of the previous edition: ‘Drawing on their wealth of experience and knowledge in this field, the authors, who are without doubt among the finest minds in pharmacognosy today, provide useful and fascinating insights into the history, botany, chemistry, phytotherapy and importance of medicinal plants in some of today's health care systems. This is a landmark textbook, which carefully brings together relevant data from numerous sources and provides in an authoritative and exhaustive manner, cutting edge information that is relevant to pharmacists, pharmacognocists, complementary practitioners, doctors and nurses alike.’ The Pharmaceutical Journal ‘This is the first book that I have encountered which combines the compounds and plants found in standard pharmacognosy textbooks, i.e. those used in orthodox Western medicine, with the 'new phytopharmaceuticals' which have become established in Western culture over the last 20 years. The medical establishment in this environment is finally catching up with the practices of the general population and so this book is an excellent choice for those who wish to investigate which of the many plants available have some scientific credence. I shall be adding this book to the Essential Reading list for all of the undergraduate students on our pharmacy degree course and would encourage all those involved in teaching pharmacy students to do the same." P.J. Houghton, Department of Pharmacy, King's College London, Journal of Ethnopharmacology ‘Educated pharmacists no doubt equate Pharmacognosy with hours spent hunched over a microscope identifying vegetable drugs. Many probably consider it as a subject with little importance in a modern pharmacy curriculum. How wrong they are! ... This book is designed to give an overview at an easy-to-understand level of a broad subject area... For students of science and of the healthcare professions it is a useful text and the authors are to be commended for their work.’ Irish Pharmacy Journal From customer reviews: ‘A new classic. This is an excellent publication both for science students and the non scientific who have an interest in phytotherapy. The layout is logical and clearly set out. I love the chemical structural diagrams, and the explanations of even complex sequences are easy to understand with very little jargon. It is encouraging to see pharmacognosy being given a prominent place in a modern textbook, and interesting to see both hand drawings and chemical structures on the same page!’ ‘I can recommend this to anyone who is interested in the science behind herbal products and medicines; especially if you are interested in plants. It's quite simple to follow and very concise! Good for pharmacy students.’ ‘This is an ultimate textbook in this subject and a boon for students of M Pharmacy (Pharmacognosy) as well as undergraduates students of Pharmacy. Besides them, it is really suitable for every course comprising a study of plants and their medicinal use.’ ‘Excellent reference book. As an editor, I instantly found the answers to various questions I had regarding botanical descriptions. And it even answered questions that I hadn't gotten around to asking. Highly recommended!’

Bioactive Compounds from Natural Sources

Isolation, Characterization and Biological Properties

Author: Corrado Tringali

Publisher: CRC Press

ISBN: 9780203212318

Category: Science

Page: 693

View: 2321

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Interest in obtaining biologically active compounds from natural sources has recently spiked due to their low toxicity, complete biodegradability, availability from renewable sources, and in most cases, low cost. Taking an interdisciplinary approach, Bioactive Compounds from Natural Sources: Isolation, Characterization, and Biological Properties covers general methods and main topics in the research field of bioactive natural products. The book describes general screening methods, modern HPLC hyphenated techniques, and NMR methods in the structural elucidation of compounds and devotes individual chapters to specific topics of research. Surveys on compounds displaying important pharmacological activities are presented in chapters devoted to Mexican medicinal plants, anti-tumor drugs of natural origin, cancer chemopreventive flavonoids, and metabolites displaying anti-HIV, antioxidative, antimalarial, and anti-inflammatory activity. The final chapters are devoted to representative examples of research into marine metabolites: immunomodulating marine glycolipids and surveys of bioactive compounds from marine opisthobranchs and Japanese soft corals. With its focus on modern approaches to the isolation of biologically active natural products, this book encourages interdisciplinary work among chemists, pharmacologists, biologists, botanists, and agronomists with an interest in bioactive natural products.

Natural products

their chemistry and biological significance

Author: J. Mann

Publisher: Longman

ISBN: 9780582060098

Category: Science

Page: 455

View: 727

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This highly informative text explores the structure, chemistry, biosynthesis and interaction of natural organic compounds, and their synthesis in the laboratory. The result is a fascinating insight into the underlying chemistry of life processes. The book also identifies the possible roles of natural products such as toxins, psychomimetics and pharmaceuticals. Each chapter is devoted to a particular class of compound and provides a broad coverage by focusing on both primary and secondary metabolite. "Natural Products" takes a chemical viewpoint but biological interrelationships are also discussed.

Biogenesis of Natural Products

Author: Baldev Kumar,Harish Kumar Chopra

Publisher: Alpha Science Int'l Ltd.

ISBN: 9781842652824

Category: Science

Page: 296

View: 3927

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Starting with photosynthesis, the authors have derived a very lucid, logical approach from CO2 and H2O to complicated structures of alkaloids, terpenes and many other natural products. This approach is based on the basic principles of Organic reaction mechanism which though taken from other research studies, have been shown to be followed in nature. In addition to the basic formulations of Acetate hypothesis, and Mevlonic pathways, newer non mevalonic paths have also been discussed and differences pointed out. As there is a limit to the inclusion of natural products in this text, only those cases are taken, in which basic principles are involved e.g. in alkaloids biosynthesis and basic amino acids which show their pathway in biosynthesis. The material has been arranged in a sequence as to how a teacher of biosynthesis should/would teach this subject.

Greene's Protective Groups in Organic Synthesis

Author: Peter G. M. Wuts

Publisher: John Wiley & Sons

ISBN: 1118905121

Category: Science

Page: 1400

View: 9334

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An indispensable reference for any practicing synthetic organic or medicinal chemist, this book continues the tradition of Greene’s as comprehensive in the overall scope of coverage, providing the most relevant and useful examples to illustrate each methodology. • Presents valuable material, on the application of protective groups in organic chemistry, that is not easily found by casual searching • Helps chemists to plan, investigate, and carry out organic syntheses in an efficient manner • Adds over 2800 new references to update since the publication of the last edition • Reviews of the prior edition: "An essential bible for the library or personal bookshelf of chemists performing complex synthesis." (CHOICE, May 2007) "...the most up-to-date compilation available...should be an integral part of all institutional libraries...it is also highly recommended that individuals...maintain their own copy..." (Journal of Medicinal Chemistry, March 8, 2007) "...continues to be a comprehensive guide to the techniques for the formation and cleavage of protective groups." (Journal of the American Chemical Society, January 31, 2007)

Anticancer Agents from Natural Products, Second Edition

Author: Gordon M. Cragg,David G. I. Kingston,David J. Newman

Publisher: CRC Press

ISBN: 1439813825

Category: Science

Page: 767

View: 5581

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The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.

Aromatic Chemistry

Author: John D. Hepworth,David R. Waring,Michael J. Waring

Publisher: Royal Society of Chemistry

ISBN: 9780854046621

Category: Education

Page: 168

View: 6168

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This book provides material required by undergraduate students and is also ideal for industrial chemists seeking to update their knowledge of this important aspect of chemistry.

Bioactive Natural Products

Chemistry and Biology

Author: Goutam Brahmachari

Publisher: John Wiley & Sons

ISBN: 3527337946

Category: Science

Page: 544

View: 3713

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A multi-disciplinary survey of current topics and future trends in natural products research, with a focus on pharmaceutical and medical applications.

Comprehensive Natural Products II: Chemistry and Biology

Author: N.A

Publisher: Elsevier

ISBN: 0080453821

Category: Science

Page: 7388

View: 5805

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This work presents a definitive interpretation of the current status of and future trends in natural products—a dynamic field at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids, and enzymes. With more than 1,800 color figures, Comprehensive Natural Products II features 100% new material and complements rather than replaces the original work (©1999). Reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine Stimulates new ideas among the established natural products research community—which includes chemists, biochemists, biologists, botanists, and pharmacologists Informs and inspires students and newcomers to the field with accessible content in a range of delivery formats Includes 100% new content, with more than 6,000 figures (1/3 of these in color) and 40,000 references to the primary literature, for a thorough examination of the field Highlights new research and innovations concerning living organisms and their distinctive role in our understanding and improvement of human health, genomics, ecology/environment, and more Adds to the rich body of work that is the first edition, which will be available for the first time in a convenient online format giving researchers complete access to authoritative Natural Products content

Natural Product Chemistry

A mechanistic, biosynthetic and ecological approach

Author: Kurt Torssell

Publisher: Swedish Pharmaceutical Press

ISBN: 9789186274634

Category: Science

Page: 480

View: 1092

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This book will be of interest to senior undergraduate and postgraduate students of organic chemistry, biochemistry, biology and pharmacology, medical chemistry and research laboratories.

Food Biosynthesis

Author: Alexandru Mihai Grumezescu,Alina Maria Holban

Publisher: Academic Press

ISBN: 0128112085

Category: Technology & Engineering

Page: 488

View: 1809

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Food Biosynthesis, Volume One in the Handbook of Food Bioengineering series, describes the main aspects related to the biological production of synthetic ingredients and natural foods, highlighting the impact of bacteria and plants in the biosynthesis of key food components. Biosynthesis methods could help solve issues like food shortages, providing consumers with preferred ‘natural’ food options. This book represents how biologically synthesized ingredients, such as vanilla flavoring, soy, milk and egg substitutes can be utilized as a desired option future foods. It is ideal for scientists and researchers who want to improve their knowledge on the field of food biosynthesis. Presents practical approaches of biosynthesis and the impact of biological origin on the field of food engineering Offers alternative applications to produce natural foods Includes processes and techniques to produce health promoting foods Discusses the positive effects of biosynthesis on microbial production to enhance food safety Offers a variety of perspectives on biosynthesis and its benefits for food ingredient production

Bioactive Natural Products

Detection, Isolation, and Structural Determination, Second Edition

Author: Steven M. Colegate,Russell J. Molyneux

Publisher: CRC Press

ISBN: 9781420006889

Category: Science

Page: 624

View: 1135

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Bioactive natural products are proving to be a rich source of novel therapeutics to both protect against and combat diseases, as well as serve as lead compounds in crop protection. Following the successful format of the first edition, this volume brings together collective research from many new contributors and emphasizes the rationale behind the successful detection, isolation, and structure determination of specific compounds. The text encompasses a diverse range of techniques that can be applied to terrestrial and aquatic sources. It also allows you to understand how source material can be selected to enhance your opportunity to discover and utilize novel bioactive natural products. New to the Second Edition— · Advances in the application of NMR spectroscopy and mass spectrometry, bioactive chemical detection and extraction, dereplication, and novel bioassay development · New case studies and illustrations that demonstrate the practical applications of specific techniques · A group of new contributors presenting research from their own laboratories that emphasize both the philosophy and rationale behind detection, isolation, and structural determination Following an overview of natural product chemistry techniques and approaches, many new chapters discuss selection of source material, quantitative NMR, high speed counter-current chromatography, dereplication of extracts, and methods to determine the stereochemistry of bioactive natural products. Examinations of new technologies including LC-NMR, biosensors, and biofingerprinting accompany discussions on the search for specific activities in anticancer and antimalarial applications, seed germination stimulation, and mammalian toxicity. With the participation from active researchers, this definitive work supplies a vital extension and an enduring contribution to the science and art of bioactive natural product detection, isolation, and structural determination.

Chemical Biology of Natural Products

Author: David J. Newman,Gordon M. Cragg,Paul Grothaus

Publisher: CRC Press

ISBN: 1351643282

Category: Medical

Page: 622

View: 4077

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Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.

Hypothalamic Hormones

Author: Choh Hao Li

Publisher: Elsevier

ISBN: 0323155138

Category: Medical

Page: 342

View: 1387

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Hypothalamic Hormones is a collection of papers that elucidates the various aspects, chemical properties, effects, and history of hypothalamic hormones. The book is composed of five chapters on the detailed study of hypothalamic hormones. Chapter 1 is about a review of basic and clinical studies of corticotropin releasing factor (CRF); thyrotropin releasing hormone (TRH); prolactin releasing factor; prolactin-release inhibiting factor; factors affecting the release of melanotropin; luteinizing hormone release hormone (LHRH); growth hormone release factor; and somatostatin. The second chapter is a discussion on the various aspects of luteinizing hormone release hormone (LHRH). Subsequent chapters are concerned with the study of factors that control the secretion of growth hormone, with particular emphasis on brain neurotransmitters; the mechanism of action of hypothalamic hormones; and effects of androgens, estrogens, and other peripheral hormones on the hypothalamus function. The last chapter gives a history of neurosecretion and neuroendocrinology. Biochemists, physicians, pharmacologists, endocrinologists, researchers, and students in the medical field will find this book invaluable.