Nutritional Genomics

Discovering the Path to Personalized Nutrition

Author: Jim Kaput,Raymond L. Rodriguez

Publisher: John Wiley & Sons

ISBN: 0471781789

Category: Technology & Engineering

Page: 480

View: 4806

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The definitive guide to the basic principles and latest advances inNutritional Genomics Though still in its infancy, nutritional genomics, or"nutrigenomics," has revealed much about the complex interactionsbetween diet and genes. But it is in its potential applicationsthat nutrigenomics promises to revolutionize the ways we managehuman health and combat disease in the years ahead. Great progressalready has been made in modeling "personalized" nutrition foroptimal health and longevity as well as in genotype-based dietaryinterventions for the prevention, mitigation, or possible cure of avariety of chronic diseases and some types of cancer. Topics covered include: * Nutrients and gene expression * The role of metabolomics in individualized health * Molecular mechanisms of longevity regulation and calorierestriction * Green tea polyphenols and soy peptides in cancer prevention * Maternal nutrition and fetal gene expression * Genetic susceptibility to heterocyclic amines from cookedfoods * Bioinformatics and biocomputation in nutrigenomics * The pursuit of optimal diets Written by an all-star team of experts from around the globe, thisvolume provides an integrated overview of the cutting-edge field ofnutritional genomics. The authors and editors lead an in-depthdiscussion of the fundamental principles and scientificmethodologies that serve as the foundation for nutritional genomicsand explore important recent advances in an array of relateddisciplines. Each self-contained chapter builds upon itspredecessor, leading the reader seamlessly from basic principles tomore complex scientific findings and experimental designs.Scientific chapters are carefully balanced with those addressingthe social, ethical, regulatory, and commercial implications ofnutrigenomics.

Nutrition for a Better Life

A Journey from the Origins of Industrial Food Production to Nutrigenomics

Author: Peter Brabeck-Letmathe

Publisher: Campus Verlag

ISBN: 3593434571

Category: Business & Economics

Page: 220

View: 5630

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In Nutrition for a Better Life, one of the food industry's leading experts takes a factual look into the past and future of food and nutrition. Former Nestlé CEO Peter Brabeck-Letmathe shows that while in the past forty years convenience was the selling point for many industrially produced foods, consumers have now come to demand specifically healthy products. Going forward, it is health that will drive innovation in the industry. Using cutting-edge technology and scientifically based nutrition standards, the food industry will play a decisive role in improving the wellbeing of entire population groups, offering effective and cost-saving personalized diets that will both prevent and administer to the acute and chronic diseases of the twenty-first century.

Nutrition and Genomics

Issues of Ethics, Law, Regulation and Communication

Author: David Castle,Nola Ries

Publisher: Academic Press

ISBN: 9780080920825

Category: Technology & Engineering

Page: 312

View: 8261

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Nutrigenomics is the rapidly developing field of science that studies nutrient-gene interaction. This field has broad implications for understanding the interaction of human genomics and nutrition, but can also have very specific implications for individual dietary recommendations in light of personal genetics. Predicted applications for nutrigenomics include genomics-based dietary guidelines and personalized nutrition based on individual genetic tests. These developments have sweeping ethical, legal and regulatory implications for individuals, corporations and governments. This book brings together experts in ethics, law, regulatory analysis, and communication studies to identify and address relevant issues in the emerging field of nutritional genomics. Contributing authors are experts in the social aspects of biotechnology innovation, with expertise in nutrigenomics. From addressing the concern that nutrigenomics will transform food into medicine and undermine pleasures associated with eating to the latest in the science of nutrigenomics, this book provides a world-wide perspective on the potential impact of nutrigenomics on our association with food. *Explores the rapidly developing, yet not fully understood, impact of nutrigenomics on the relationship to food medicalization, genetic privacy, nutrition and health. *Provides ground for further exploration to identify issues and provide analysis to aid in policy and regulation development *Provides ethical and legal insights into this unfolding science, as well as serving as a model for thinking about issues arising in other fields of science and technology

Ernährung für ein besseres Leben

Eine Reise von den Anfängen der industriellen Nahrungsproduktion zur Nutrigenomik

Author: Peter Brabeck-Letmathe

Publisher: Campus Verlag

ISBN: 3593434563

Category: Business & Economics

Page: 250

View: 7376

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Wo die Lebensmittelindustrie ihre Zukunft sieht Durch die Fortschritte in den Biowissenschaften - vor allem der Genetik - sehen wir den Zusammenhang von Ernährung und Gesundheit heute in einem vollkommen neuen Licht. Wir können unsere Gesundheit und Lebensqualität nachhaltig optimieren, wenn wir unsere Ernährung auf wissenschaftlicher Grundlage neu gestalten. Peter Brabeck-Letmathe wirft einen Blick hinter die Kulissen der Forschung: Werden wir Zivilisationskrankheiten wie Bluthochdruck und Diabetes in Zukunft durch personalisierte Nahrungsmittel in den Griff bekommen? Dieses Buch verrät, woher die Lebensmittelindustrie weiß, was unseren Genen schmeckt.

Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition

Author: Lynnette R. Ferguson

Publisher: CRC Press

ISBN: 1439876819

Category: Medical

Page: 451

View: 2615

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While functional foods have become a reasonably well-established concept, personalized nutrition is still treated with skepticism by many. The recognition that people would have different nutrient requirements, or perceive foods in different ways, raises several concerns—some real, some not so real. Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition addresses what is needed to bring nutrigenomics, nutrigenetics, and their associated technologies to market in a truly impactful way. Edited by Lynnette R. Ferguson, a well-known and internationally respected researcher, the book covers a wide range of issues, from the purely scientific to ethical, consumer-driven, and public health aspects. It takes a close look at gene–diet interactions and explores the ways in which studies on nutrigenomics and nutrigenetics can help modulate disease risk in cardiovascular disease, obesity, diabetes, and inflammatory bowel disease. Topics include regulatory challenges, genetic testing for consumers, data mining, transcriptomic analysis, and the role of science and health professionals in the commercialization of nutrigenomics and nutrigenetics. The book also examines industry–academia partnerships as a nexus between the science and its commercialization by the food industry. These partnerships will be an important determinant of what value the technologies bring, not only to the market but to the wider health and well-being of society. Exploring how nutrigenomics and nutrigenetics can help modulate disease risk, this timely book brings together stimulating, well-thought-out perspectives from established and emerging researchers. It provides valuable information on a subject that is becoming increasingly important for nutritionists, dieticians, and clinical professionals, as well as for the food industry and research community.

Nutrigenetics and Nutrigenomics

Author: Artemis P. Simopoulos,J. M. Ordovas

Publisher: Karger Medical and Scientific Publishers

ISBN: 3805577826

Category: Health & Fitness

Page: 324

View: 6284

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For the first time, international scientists describe the advances in genetics and nutrition by combining methods of molecular biology with those of functional genetics, also known as systems biology. This book provides the latest data on genetic variation and dietary response, nutrients and gene expression, and the contribution molecular biology has given to systems biology. It also includes a comprehensive critique of genetic association studies in defining the risk of chronic diseases and concludes that molecular diagnostic tests will eventually affect every area of health care from individual risk prediction, early diagnosis of disease, and determination of optimal treatment regimens, to monitoring treatment effectiveness. The appendix contains an extensive glossary of the newly emerging terminology, as well as recommendations for genetic screening. This publication is an essential tool for the future work of all physicians, nutritionists, dietitians, geneticists, physiologists, molecular biologists, anthropologists, food technologists, policy makers, ethicists and educators.

Nutrigenomics

Author: Gerald Rimbach,Jürgen Fuchs

Publisher: CRC Press

ISBN: 142002809X

Category: Medical

Page: 504

View: 7090

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Nutritional genomics, also referred to as nutrigenomics, is considered one of the next frontiers in the post-genomic era. Its fundamental premise is that while alterations in gene expression or epigenetic phenomena can subvert a healthy phenotype into manifesting chronic disease, through the introduction of certain nutrients, this process can be reversed or modified. Employing state-of-the-art genomic and proteomic investigations that monitor the expression of thousands of genes in response to diet, nutrigenomics investigates the occurrence of relationship between dietary nutrients and gene expression. Nutrigenomics was compiled to update the reader on recent advances in this emerging field. Over forty experts in nutrition, physiology, pathology, pharmacology, and the microbial sciences from all across the world present cutting-edge developments and emerging methods presently used in nutrigenomics. They include the latest studies and research on the role of oxidants, antioxidants, phytochemicals, and micronutrients in the modulation of gene expression affecting aging, immune function, carcinogenesis, and vascular health. As most human diseases are largely avoidable by lifestyle changes, this places nutrigenomics at the forefront of preventive medicine.

Personalized Nutrition

Translating Nutrigenetic/nutrigenomic Research Into Dietary Guidelines

Author: Artemis P. Simopoulos,John A. Milner

Publisher: Karger Medical and Scientific Publishers

ISBN: 3805594275

Category: Medical

Page: 180

View: 8257

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Awareness of the influence of our genetic variation to dietary response (nutrigenetics) and how nutrients may affect gene expression (nutrigenomics) is prompting a revolution in the field of nutrition. Nutrigenetics/Nutrigenomics provide powerful approaches to unravel the complex relationships among nutritional molecules, genetic variants and the biological system. This publication contains selected papers from the '3rd Congress of the International Society of Nutrigenetics/Nutrigenomics' held in Bethesda, Md., in October 2009. The contributions address frontiers in nutrigenetics, nutrigenomics, epigenetics, transcriptomics as well as non-coding RNAs and posttranslational gene regulations in various diseases and conditions. In addition to scientific studies, the challenges and opportunities facing governments, academia and the industry are included. Everyone interested in the future of personalized medicine and nutrition or agriculture, as well as researchers in academia, government and industry will find this publication of the utmost interest for their work.

Nutrigenomics

Opportunities in Asia

Author: E. Shyong Tai,Peter J. Gillies

Publisher: Karger Medical and Scientific Publishers

ISBN: 3805582161

Category: Medical

Page: 248

View: 5821

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Nutrigenomics seeks to understand the variability of the individual's response to food and the underlying mechanisms whereby foods exert their health-promoting activities. With a deeper molecular understanding of nutrition, we may some day be able to design diets that truly maximize an individual's potential for health and wellness. Many Asian societies are currently experiencing a transition in diet-related morbidity and mortality. The identification and provision of an optimal diet relevant to all the people living in Asia is an extraordinary challenge as there exists a tremendous diversity in diet, dietary intake patterns, local culture, and nutritional needs. This volume explores the role of ethnic diversity, dietary patterns and genetic adaptation in determining individual nutrient requirements throughout the life-cycle. Conceptualized as an introductory publication providing a general overview as well as specific examples of the applications of concepts and methods, this publication will help scientists, medical, nutrition and other health professionals to learn more about the field of nutrigenomics.

Advances in Food Biochemistry

Author: Fatih Yildiz

Publisher: CRC Press

ISBN: 9781420007695

Category: Technology & Engineering

Page: 522

View: 7785

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Understanding the biochemistry of food is basic to all other research and development in the fields of food science, technology, and nutrition, and the past decade has seen accelerated progress in these areas. Advances in Food Biochemistry provides a unified exploration of foods from a biochemical perspective. Featuring illustrations to elucidate molecular concepts throughout the text, this volume examines a range of issues on the food spectrum, including: water and its relation to food the glycobiology of food components enzymes plant, animal, and human hormones functional foods, herbs, and dietary supplements flavor compounds in foods organic acids interactions between the environment with food components biological and lipid oxidation in foods food safety nutrition and the genetic makeup of individual food components Dr. Fatih Yildiz has published an extensive body of research and has worked on food and nutrition science projects with the FAO, UNIDO, UNICEF, and NATO. Recently he received the Ambassador for Turkey Award from the European Federation of Food Science and Technology. Dr. Yildiz and the contributors to this volume have brought together their decades of experience and expertise to provide a top-notch resource for food science and policy professionals and advanced students on the cutting edge of food research.

Nutritional Genomics

The Impact of Dietary Regulation of Gene Function on Human Disease

Author: Wayne R. Bidlack,Raymond L. Rodriguez

Publisher: CRC Press

ISBN: 1439844534

Category: Medical

Page: 448

View: 2220

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The notion of matching diet with an individual’s genetic makeup is transforming the way the public views nutrition as a means of managing health and preventing disease. To fulfill the promise of nutritional genomics, researchers are beginning to reconcile the diverse properties of dietary factors with our current knowledge of genome structure and gene function. What is emerging is a complex system of interactions that make the human genome exquisitely sensitive to our nutritional environment. Nutritional Genomics: The Impact of Dietary Regulation of Gene Function on Human Disease provides an integrated view of how genomic and epigenetic processes modulate the impact of dietary factors on health. Written as a resource for researchers, nutrition educators, and policy makers, this book contains the latest scientific findings on the mechanisms of action underlying diet-genome interactions. It presents a unique perspective on the fundamentals of nutritional genomics from genomics, transcriptomics, proteomics, and metabolomics. Contributing authors introduce the important areas of cell signaling and transduction, the intricate regulation of gene expression, and alteration of gene-linked chronic diseases, such as obesity-induced inflammation, insulin resistance, metabolic syndrome, cardiovascular disease, and cancer. The authors detail significant areas of interest within nutritional genomics—including plant-based foods as epigenetic modifiers of gene function and the effects of bioactive phytochemicals on inherited genotype and expressed phenotypes. They also discuss the role of vitamin D in various cancer risks and the gastrointestinal tract as a defense system. Given the key role played by agriculture and the food industry to produce foods to meet personalized health needs, the book also addresses agricultural breeding efforts to enhance nutritional value and the use of technology to increase bioactive ingredients in the food supply. The final chapters discuss manufacturing practices and novel processing techniques for retention of nutrients and bioactive components, as well as the need for regulatory oversight and proper labeling to establish assurance of safety and benefit. An excellent resource for this exciting field, the book identifies future directions for research and opportunities for improving global health and wellness by preventing, delaying, or mitigating chronic diseases with diet.

Food Science and Technology Bulletin

Functional Foods

Author: Glenn Gibson

Publisher: IFIS Publishing

ISBN: 0860141721

Category: Medical

Page: 104

View: 9312

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Food Science and Technology Bulletin: Functional Foods is an online minireview journal that delivers concise and relevant peer-reviewed minireviews of developments in selected areas of functional foods. Newly published minireviews are compiled to form an annual printed volume. Contents for Volume 3 of the Bulletin include minireviews on: Nutrigenomics - new frontiers in antioxidant research; Dietary fat composition and cardiovascular disease; Phytochemicals - a future in functional foods? Inulin: a prebiotic functional food ingredient; Assessment of the efficacy of probiotics, prebiotics and synbiotics in swine nutrition; Lactitol, an emerging prebiotic; Guidelines for an evidence-based review system for the scientific justification of diet and health relationships under Article 13 of the new European legislation on nutrition and health claims

Nutrigenomics and Beyond

Informing the Future: Workshop Summary

Author: Institute of Medicine,Food and Nutrition Board

Publisher: National Academies Press

ISBN: 9780309179874

Category: Science

Page: 90

View: 2421

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The integration of biology, genomics, and health has opened the possibility of applying genomics technology to nutrition. In 2001, scientists associated with the Human Genome Project announced the successful mapping of the reference sequence of the human genome. Since then, a body of information has emerged. Genomics and related areas of research have contributed greatly to efforts to understand the cellular and molecular mechanisms underlying diet-disease relationships. Integration and application of genetic and genomics technology into nutrition research is, therefore, needed to develop nutrition research programs that are aimed at the prevention and control of chronic disease through genomics-based nutritional interventions. Of interest is the integration of relevant computational methods into nutritional genomics research; the enhancement of tools applicable to systems biology; and the effective dissemination of genomics-derived information to scientists, policy makers, and the interested public. To address these issues, a workshop was held on June 1 and 2, 2006. The workshop included presentations that were structured around three focus sessions: human genetic variation, epigenetics, and systems biology. A fourth session presented discussions on the implications of nutrigenomics for the future of nutrition science research. Numerous themes emerged from the workshop presentations. First, nutrigenomics is a complex field because it addresses issues related to multigenetic traits that can be modified by a number of nutritional and other environmental factors. Such complexity presents a challenge to the field; and the ensuing research opportunities will require cooperative work among scientific disciplines and across government, academic, and industrial centers, as well as adequate funding, to be realized. Additionally, the ability to stretch the limits of conventional research methodologies afforded by new genetic and genomic applications at the level of the individual opens the door to a wealth of potential benefits to areas such as disease prevention and wellness, bearing in mind the necessity of ethical safeguards. This potential, however, must be wisely exploited to avoid the pitfalls of overpromising research results and prematurely setting unrealistic expectations for beneficial outcomes. Finally, careful and rigorous research must be employed to optimize outcomes and assure acceptance by the scientific community. In summary, nutrition science is uniquely poised to serve as the crossroads for many disciplines and, using genomics tools, can bring this knowledge together to better understand and address diet-related chronic diseases and molecular responses to dietary factors.

Recent Advances in Nutrigenetics and Nutrigenomics

Author: Claude Bouchard,J. M. Ordovas

Publisher: Academic Press

ISBN: 0123983975

Category: Medical

Page: 502

View: 1961

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This volume of Progress in Molecular Biology and Translational Science covers the recent advances in the expanding fields of nutrigenetics and nutrigenomics. Forty authors from eight countries have contributed to the publication, representing the most cutting-edge research available. Covers recent advances in nutrigenetics and nutrigenomics Distinguished panel of 40 authors from eight different countries

Science, Society, and the Supermarket

The Opportunities and Challenges of Nutrigenomics

Author: David Castle,Cheryl Cline,Abdallah S. Daar,Charoula Tsamis,Peter A. Singer

Publisher: John Wiley & Sons

ISBN: 0470055499

Category: Technology & Engineering

Page: 192

View: 2625

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The new science of nutrigenomics and its ethical and societal challenges Gene-diet interactions--which underlie relatively benign lactose intolerance to life-threatening conditions such as cardiovascular disease--have long been known. But until now, scientists lacked the tools to fully understand the underlying mechanisms that cause these conditions. In recent years, however, strides in human genomics and the nutritional sciences have allowed for the advancement of a new science--dubbed nutrigenomics. Although this science may lead to personalized nutrition and dietary recommendations that can mitigate, prevent, or cure sickness, current oversight mechanisms and regulations for emerging direct-to-public nutrigenomic tests are still in their infancy. Science, Society, and the Supermarket: The Opportunities and Challenges of Nutrigenomics discusses the many ethical, legal, and social challenges presented by nutrigenomics. Concerning itself with the basic uses of nutrigenomic research as well as its clinical and commercial aspects, this text sheds light on such issues as: * Opportunities and challenges for nutrigenomics * The science of nutrigenomics * The ethics of nutrigenomic tests and information both in a clinical setting and by private third parties * Alternatives for nutrigenomics service delivery * Nutrigenomics and the regulation of health claims for foods and drugs * Equity and access to nutrigenomics in industrialized and developing countries * Intellectual property issues By taking a proactive bioethical stance on the subject, Science, Society, and the Supermarket offers a thorough and timely analysis on both the benefits and risks of nutrigenomics. Along with a thought-provoking examination of the issues, this book provides ethical guidelines and recommendations for further study in policy and regulatory development.

Design of Human Nutrigenomics Studies

Author: Siân Astley,L. Penn

Publisher: Wageningen Academic Pub

ISBN: 908686094X

Category: Technology & Engineering

Page: 100

View: 6949

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The key to exploiting links between diet and health is to have a better understanding of how our bodies respond to what we eat. In the past, many food constituents were regarded as unimportant because they lacked a specific nutritional role. More recently nutritional research has been limited to a few dietary compounds, a handful of relevant biochemical pathways and a small number of genes pertinent to specific diseases. These studies have given rise to specific examples of benefits provided by individual/ groups of food compounds including non-nutrients, and demonstrated that whilst poor diet can accelerate age-related degeneration, a diet rich in fruits and vegetables, cereals and plant oils significantly reduces our risk of chronic disease. However, the benefits of dietary and lifestyle choices are not the same for everyone.Nutrigenomics offers a more holistic approach to nutritional research. It considers not only our genes and the effect they have on our response to diet but, also how diet affects our genes and proteins to alter our metabolism and our risk of disease as we age. However, the logistics associated with human study design and interpretation of the data generated, using these technologies, is complex. The European Network of Excellence NuGO was established in 2004 with the specific aim of developing and integrating omic technologies for European nutritional research. This has meant focusing on technical problems specific to nutrition as well as training existing and new researchers to use the technology alongside existing and new approaches. The workshop, Design of human nutrigenomic studies, reviewed examples of successful human nutrition studies using post-genomics technologies (transcriptomics, metabolomics, and proteomics) and the issues discussed are described in detail in this publication.

Nutritional Genomics

Impact on Health and Disease

Author: Regina Brigelius-Flohé,Hans-Georg Joost

Publisher: John Wiley & Sons

ISBN: 3527607757

Category: Science

Page: 470

View: 8827

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Nutritional genomics paves the way for novel applications in medicine and human nutrition, and this volume presents the latest data on how genetic variation is associated with dietary response and how nutrients influence gene expression. In so doing, it brings together the various disciplines involved in this field of research, making this essential reading for nutritionists, biochemists and molecular biologists.

Molecular Nutrition and Genomics

Nutrition and the Ascent of Humankind

Author: Mark Lucock

Publisher: John Wiley & Sons

ISBN: 9780470129371

Category: Medical

Page: 288

View: 3102

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This fascinating book draws it subject matter from a range of relevant disciplines that extend from molecular nutrition, nutritional sciences, and nutrition dietetics through to genetics, genomics, and anthropology. It presents a vital portrait of the absolutely fundamental role that nutrition has played and continues to play in shaping who and what human beings are, as well as where they evolved from, and where they may be heading as a species. Molecular Nutrition: Nutrition and the Evolution of Humankind: Blends coverage of the molecular mechanisms that underpin nutrient-gene interactions with evolutionary theory Takes a molecular biological approach to problem solving, and moves nutrition away from its dietetic and anthropological origins to the front lines of genomic research Covers key concepts in molecular biology; the –omics revolution and bioinformatics; recent human evolution; molecular mechanisms of gene-nutrient interactions; the importance of nutrients and genomics in disease; the evolution of micronutrient metabolism, protein structure, and human disease; nutrients and the human lifecycle; contemporary dietary patterns; leading-edge laboratory tools in nutrigenomics and human evolutionary studies Written by an internationally recognised expert in the field, Molecular Nutrition: Nutrition and the Evolution of Humankind is an invaluable text and reference book for a wide range of teachers, students, and researchers.

Nutrigenomics and Proteomics in Health and Disease

Towards a Systems-level Understanding of Gene-diet Interactions

Author: Martin Kussmann,Patrick J. Stover

Publisher: John Wiley & Sons

ISBN: 1119098831

Category: Medical

Page: 344

View: 6383

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"This volume brings together leading experts in the areas of nutrition, nutrigenomics, metabolic programming, food-based bioactive dietary components and the gut microbiome, as well as those expert in the application of innovative tools and methods for statistical and biological network analysis, which are now at the forefront of nutritional and biomedical sciences. The articles provide a roadmap for the integration of normative science methods and approaches with more comprehensive systems biology-based investigations that deploy a multitude of omic platforms. This integration is essential to escape the bottleneck in knowledge generation by applying decades of knowledge of nutrients and their function to comprehensive omics and clinical data acquisition, processing, visualization, and interpretation. Achieving a systems-level understanding of nutrient function in health and disease will usher in an age of precision nutrition in support of maximizing human health and potential"--

Nutrigenomics and Proteomics in Health and Disease

Food Factors and Gene Interactions

Author: Yoshinori Mine,Kazuo Miyashita,Fereidoon Shahidi

Publisher: John Wiley & Sons

ISBN: 9780813807171

Category: Technology & Engineering

Page: 412

View: 2729

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Part of the Functional Food Science and Technology book series (Series Editor: Fereidoon Shahidi), this book compiles the current science based upon nutrigenomics and proteomics in food and health. Coverage includes many important nutraceuticals (food factors) and their impact on gene interaction and health. Authored by a stellar international team of multidisciplinary researchers, this book acquaints food and nutrition professionals with these new fields of nutrition research and conveys the state of the science to date.