Top Drugs: Top Synthetic Routes

Author: John Saunders

Publisher: OUP Oxford

ISBN: 9780198501008

Category: Science

Page: 96

View: 7278

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This book will allow students to see how the organic chemistry taught in undergraduate courses is applied by medicinal chemists in industry. Many of today's best selling drugs are first made in the chemical laboratory on a very small scale many years before they enter the market place. During the intervening period, organic chemists investigate alternative methods both to improve the overall yield of the process and to ensure that it operates safely on a manufacturing scale. This book describes briefly how each drug works and then reviews the most efficient routes to their synthesis.

Organometallic Reagents in Synthesis

Author: Paul R. Jenkins

Publisher: Oxford University Press on Demand

ISBN: 9780198556664

Category: Science

Page: 91

View: 5835

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This straightforward introduction looks at the properties and reactions of main group organometallic compounds, placing particular emphasis on their applications in synthesis. The book adopts a logical approach to this important area of organic chemistry, providing the student with a clear account of all aspects of the field.

Practical Process Research and Development

Author: Neal G. Anderson

Publisher: Elsevier

ISBN: 0080514480

Category: Science

Page: 354

View: 8746

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This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Includes over 100 tips for rapid process development Presents guidelines for implementing and troubleshooting processes

Pharmaceutical Process Chemistry for Synthesis

Rethinking the Routes to Scale-Up

Author: Peter J. Harrington

Publisher: John Wiley & Sons

ISBN: 9780470922866

Category: Science

Page: 448

View: 5950

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There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

Contemporary Drug Synthesis

Author: Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth

Publisher: John Wiley & Sons

ISBN: 9780471686736

Category: Science

Page: 240

View: 9042

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An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

Chemistry of Peptide Synthesis

Author: N. Leo Benoiton

Publisher: CRC Press

ISBN: 1420027697

Category: Science

Page: 304

View: 1986

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Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author’s role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather than memorization. The text uses clear language and schematics to present concepts progressively, carefully excluding unnecessary details and providing a historical context in which to appreciate the development of the field. The author first outlines the fundamentals of peptide synthesis, focusing on the intermediates in aminolysis reactions. Gradually the text builds into discussions of the applicability of coupling reactions, stereomutation, methods of deprotection, solid-phase synthesis, side-chain protection and side reactions, and amplification on coupling methods. The book clarifies the differences between oxazolones from amino-acid derivatives and segments and the implications of their formation on the chiral integrity of products. The author offers a critical analysis of the mechanisms of coupling reactions and the desirability of preactivation. The text explains hindrance and the nucleophilicity of tertiary amines and rationalizes their use. The book also explores mechanisms of acidolysis and the dual role of nucleophiles as reactants and scavengers. Chemistry of Peptide Synthesis supplies a broad, yet straightforward approach that appeals to those with limited knowledge of organic chemistry or chemists from other fields as well as in-depth coverage that can be appreciated by experienced peptidologists.

A Natural History of Latin

Author: Tore Janson,Nigel Vincent,Merethe Damsgård Sørensen

Publisher: Oxford University Press

ISBN: 0199214050

Category: Language Arts & Disciplines

Page: 305

View: 8605

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Beginning in Rome around 600 BC, Latin became the language of the civilized world and remained so for more than two millennia. French, Spanish, Italian, and Romanian are among its progeny and it provides the international vocabulary of law and life science. No known language, including English - itself enriched by Latin words and phrases - has achieved such success and longevity. Tore Janson tells its history from origins to present. Brilliantly conceived and written with the same light touch as his bestselling history of languages, A Natural History of Latin is a masterpiece of adroit synthesis. The author charts the expansion of Latin in the classical world, its renewed importance in the Middle Ages, and its survival into modern times. He shows how spoken and written Latin evolved in different places and its central role in European history and culture. He ends with a concise Latin grammar and lists of Latin words and phrases still in common use. Considered elitist andirrelevant in the second half of the twentieth century and often even banned from schools, Latin is now enjoying a huge revival of interest across Europe, the UK, and the USA. Tore Janson offers persuasive arguments for its value and gives direct access to its fascinating worlds, past and present.

Photochemistry of Organic Compounds

From Concepts to Practice

Author: Petr Klán,Jakob Wirz

Publisher: John Wiley & Sons

ISBN: 1405190884

Category: Science

Page: 563

View: 6665

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This new volume in the Postgraduate Chemistry Series provides a thorough overview of the principles and uses of synthetic organic photochemistry. Appropriate at postgraduate and research level it will also serve as a reference for more experienced workers.

Foundations of Inorganic Chemistry

Author: Mark J. Winter,John E. Andrew

Publisher: Oxford University Press on Demand

ISBN: 9780198792888

Category: Science

Page: 91

View: 8215

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'provides up-to-date information and clearly explains some of the principles, concepts, and rationale for the foundation of current understanding in inorganic chemistry.' Education in Chemistry, November 2001Intended to complement Foundations of Organic Chemistry, the best-selling Primer by Michael Hornby and Josephine Peach, this text is a broad overview of inorganic chemistry. Writing in an informal and relaxed style, Mark Winter and John Andrew cover the basics and also highlight the industrial and environmental relevance of inorganic chemistry.

Stereoselectivity in Organic Synthesis

Author: Garry Procter

Publisher: OUP Oxford

ISBN: 9780198559573

Category: Science

Page: 98

View: 6584

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This clear and concise text is concerned with the reactions used in stereoselective organic synthesis. These are important types of reactions which can be used for the selective preparation of new organic compounds with a defined and predictable three dimensional architecture. This informative text will be an invaluable study aid for all undergraduate chemistry students. Undergraduates in related subjects studying chemistry to second year level or higher will also find this book useful.

From Bench to Market

The Evolution of Chemical Synthesis

Author: Walter Cabri,Romano Di Fabio

Publisher: Oxford University Press on Demand

ISBN: 9780198503835

Category: Business & Economics

Page: 266

View: 1732

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'... a unique book... I highly recommendthis book to process chemists not only in the pharmaceutical industry but in the fine chemical, agrochemical, and colour chemical industries, too ... It is refreshing to see the book in paperback at a low cost. Highly recommended- I will certainly use it as a teaching aid' Chemistry in BritainWho wins the race to turn molecules into medicines? How much does it cost? What factors influence the choice of synthetic routes and reaction mechanisms? How can pharmaceutical companies protect their discoveries? In From Bench to Market, Walter Cabri and Romano Di Fabio chart the process of industrial chemical synthesis, from the first discovery of a molecule to its entry in the marketplace as a drug. Using real case histories of drug development from several therapeutic areas, they discuss all aspects related to the process research for bulk production, including comparison between different synthetic routes, key methodologies and reaction mechanisms, costs, patent competition, and crystalline forms.

Writing Reaction Mechanisms in Organic Chemistry

Author: Audrey Miller,Philippa H. Solomon

Publisher: Academic Press

ISBN: 9780124967120

Category: Science

Page: 471

View: 9478

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Writing Reaction Mechanisms in Organic Chemistry, Second Edition, is an invaluable guide to charting the movements of atoms and electrons in the reactions of organic molecules. Miller and Solomon illustrate that understanding organic reactions is based on applying general principles rather than the rote memorization of unrelated processes, and, in turn, emphasize that writing mechanisms is a practical method of applying knowledge of previously encountered reactions and reaction conditions to new reactions. Students and research chemists alike will find this book useful in providing a method of organizing and synthesizing an oftentimes overwhelming quantity of information into a set of general principles and guidelines for determining and describing organic reaction mechanisms. * Essential for those students who need to have mechanisms explained in greater detail than most organic chemistry textbooks provide. * Illustrated with hundreds of chemical structures * Extensively rewritten and reorganized to make the presentation and format even easier for students to use * Contains many problem sets and answers to all problems to help students work through general principles and applications * Appendixes have been added to this edition that contain easily referenced information on Lewis structures, symbols for chemical notation, and the relative acidities of common substances

Strategic Applications of Named Reactions in Organic Synthesis

Author: Laszlo Kurti,Barbara Czako

Publisher: Elsevier

ISBN: 0080575412

Category: Science

Page: 864

View: 417

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Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. * The first reference work on named reactions to present colored schemes for easier understanding * 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples * An opening list of abbreviations includes both structures and chemical names * Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works * Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools * Extensive index quickly locates information using words found in text and drawings

Principles of Process Research and Chemical Development in the Pharmaceutical Industry

Author: Oljan Repic

Publisher: Wiley-Interscience

ISBN: 9780471165163

Category: Science

Page: 240

View: 4427

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This text discusses the functions of Process R&D (research and development), which involves the method of transforming a research synthetic procedure into a plant process and the key aspects of a synthesis that must be considered when scaling up a process. Topics consist of: basic principles of chemical development; techniques for the minimization of by-product impurities; criteria for cost-effective synthesis of enantiopure compounds by resolutions; asymmetric synthesis, and "chiral pool" strategy; synthesis for labeling substances with hydrogen or carbon isotopes; and last, licensing.

The Art of Writing Reasonable Organic Reaction Mechanisms

Author: Robert B. Grossman

Publisher: Springer Science & Business Media

ISBN: 0387954686

Category: Science

Page: 360

View: 3108

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Intended for students of intermediate organic chemistry, this text shows how to write a reasonable mechanism for an organic chemical transformation. The discussion is organized by types of mechanisms and the conditions under which the reaction is executed, rather than by the overall reaction as is the case in most textbooks. Each chapter discusses common mechanistic pathways and suggests practical tips for drawing them. Worked problems are included in the discussion of each mechanism, and "common error alerts" are scattered throughout the text to warn readers about pitfalls and misconceptions that bedevil students. Each chapter is capped by a large problem set.

Oxidation and Reduction in Organic Synthesis

Author: Timothy J. Donohoe

Publisher: Oxford University Press on Demand

ISBN: 9780198556640

Category: Science

Page: 90

View: 2495

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The manipulatin of functional groups by oxidative or reductive porcesses is central to organic chemistry. This book provides a clear and comprehensive summary of oxidative and reductive processes, emphasizing general principles and common factors, and showing the applicatins of these reactions in organic synthesis.

Foundations of Chemical Biology

Author: Christopher M. Dobson,Juliet A. Gerrard,Andrew J. Pratt

Publisher: Oxford University Press, USA

ISBN: 9780199248995

Category: Science

Page: 97

View: 7845

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This book introduces the fundamental chemistry of the molecules that are essential to all cells, covering amino acids and sugar phosphate derivatives, and the macromolecules derived from them. In such a short text it is not possible to provide a comprehensive account of such molecules; instead it covers important concepts concerning their intrinsic chemistry. The aim is to provide the fundamental ideas relating to the chemistry of life that can then be applied to more advanced aspects of chemical biology.