Organic Synthesis

Strategy and Control

Author: Paul Wyatt,Stuart Warren

Publisher: John Wiley & Sons

ISBN: 1118681444

Category: Science

Page: 920

View: 8168

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Organic Synthesis: Strategy and Control is the long-awaited sequel to Stuart Warren’s bestseller Organic Synthesis: The Disconnection Approach, which looked at the planning behind the synthesis of compounds. This unique book now provides a comprehensive, practical account of the key concepts involved in synthesising compounds and focuses on putting the planning into practice. The two themes of the book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work. The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. A comprehensive, practical account of the key concepts involved in synthesising compounds Takes a mechanistic approach, which explains reactions and gives guidelines on how reactions might behave in different situations Focuses on reactions that really work rather than those with limited application Contains extensive, up-to-date references in each chapter Students and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.

Workbook for Organic Synthesis

Strategy and Control

Author: Paul Wyatt,Stuart Warren

Publisher: Wiley

ISBN: 9780471929642

Category: Science

Page: 502

View: 9638

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This workbook accompanies Organic Synthesis: Strategy and Control, the bestselling advanced organic textbook Provides a complete course for advanced organic students and includes a graded set of problems, solutions and discussions to illustrate and develop the themes of each of the chapters in the textbook

Organic Synthesis

The Disconnection Approach

Author: Stuart Warren,Paul Wyatt

Publisher: John Wiley & Sons

ISBN: 1119965535

Category: Science

Page: 342

View: 2986

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One approach to organic synthesis is retrosynthetic analysis. With this approach a chemist will start with the structure of their target molecule and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This “disconnection” approach to synthesis is now a fundamental part of every organic synthesis course. Organic Synthesis: The Disconnection Approach, 2nd Edition introduces this important technique, to help students to design their own organic syntheses. There are forty chapters: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems. Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given. This second edition has been fully revised and updated with a modern look. Recent examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, “Organic Synthesis: Strategy and Control”. Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry. Organic Synthesis: The Disconnection Approach, 2nd edition provides a full course in retrosynthetic analysis for chemistry and biochemistry students and a refresher for organic chemists working in industry and academia.

Workbook for Organic Synthesis: The Disconnection Approach

Author: Stuart Warren,Paul Wyatt

Publisher: John Wiley & Sons

ISBN: 1119965551

Category: Science

Page: 272

View: 4669

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One approach to organic synthesis is retrosynthetic analysis. With this approach chemists start with the structures of their target molecules and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This “disconnection” approach to synthesis is now a fundamental part of every organic synthesis course. Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition This workbook provides a comprehensive graded set of problems to illustrate and develop the themes of each of the chapters in the textbook Organic Synthesis: The Disconnection Approach, 2nd Edition. Each problem is followed by a fully explained solution and discussion. The examples extend the student’s experience of the types of molecules being synthesised by organic chemists, and the strategies they employ to control their syntheses. By working through these examples students will develop their skills in analysing synthetic challenges, and build a toolkit of strategies for planning new syntheses. Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given. Together the workbook and textbook provide a complete course in retrosynthetic analysis. Organic Synthesis: The Disconnection Approach, 2nd Edition There are forty chapters in Organic Synthesis: The Disconnection Approach, 2nd Edition: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems. In its second edition updated examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, Organic Synthesis: Strategy and Control. Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry. Workbook for Organic Synthesis: The Disconnection Approach, 2nd edition, combined with the main textbook, provides a full course in retrosynthetic analysis for chemistry and biochemistry students, and a refresher course for organic chemists working in industry and academia.

Multi-Step Organic Synthesis

A Guide Through Experiments

Author: Nicolas Bogliotti,Roba Moumné

Publisher: John Wiley & Sons

ISBN: 352769899X

Category: Science

Page: 350

View: 9700

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Combining theoretical knowledge of synthetic transformations, practical considerations, structural elucidation by interpretation of spectroscopic data as well as rationalization of structure-property relations, this textbook presents a series of 16 independent exercises, including detailed descriptions of experimental procedures, questions, and answers. The experimental descriptions are very helpful for guiding less experienced students towards a better understanding of practical aspects in synthetic organic chemistry, while the broad scope of the questions and answers is excellent for learning purposes. The exercises are based on published research articles, adapted for didactic purposes, and will thus inspire students by way of having to solve real-life problems in chemistry. A must-have for MSc and PhD students as well as postdocs in organic chemistry and related disciplines, and lecturers and organizers of lab courses in organic chemistry.

The Art of Writing Reasonable Organic Reaction Mechanisms

Author: Robert B. Grossman

Publisher: Springer Science & Business Media

ISBN: 0387954686

Category: Science

Page: 360

View: 2805

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Intended for students of intermediate organic chemistry, this text shows how to write a reasonable mechanism for an organic chemical transformation. The discussion is organized by types of mechanisms and the conditions under which the reaction is executed, rather than by the overall reaction as is the case in most textbooks. Each chapter discusses common mechanistic pathways and suggests practical tips for drawing them. Worked problems are included in the discussion of each mechanism, and "common error alerts" are scattered throughout the text to warn readers about pitfalls and misconceptions that bedevil students. Each chapter is capped by a large problem set.

Organic Synthesis, Workbook

The Disconnection Approach

Author: Stuart Warren

Publisher: John Wiley & Sons

ISBN: 9780471900825

Category: Science

Page: 540

View: 1378

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A workbook providing additional examples, problems, and solutions for use with Warren′s Organic Synthesis: The Disconnection Approach. Exercises correspond to chapters in the main text. Problems of special ease or difficulty are labeled for optional use. Workbook includes a formula index of all target molecules contained in the text and workbook.

Designing Organic Syntheses

A Programmed Introduction to the Synthon Approach

Author: Stuart Warren

Publisher: John Wiley & Sons

ISBN: 9780471996125

Category: Science

Page: 285

View: 7524

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"This book confronts the student with the problem of synthesizing molecules given nothing but their structure. The synthon approach is used: disconnections breaking the molecule into useable fragments (synthons) are introduced to the student, who then teaches himself how to use them by solving a series of problems of steadily increasing difficulty"--Cover.

Strategic Applications of Named Reactions in Organic Synthesis

Author: Laszlo Kurti,Barbara Czako

Publisher: Elsevier

ISBN: 0080575412

Category: Science

Page: 864

View: 1948

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Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. * The first reference work on named reactions to present colored schemes for easier understanding * 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples * An opening list of abbreviations includes both structures and chemical names * Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works * Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools * Extensive index quickly locates information using words found in text and drawings

40 Days of Dating

An Experiment

Author: Timothy Goodman,Jessica Walsh

Publisher: ABRAMS

ISBN: 1613127154

Category: Self-Help

Page: 304

View: 2496

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“What would happen if Harry met Sally in the age of Tinder and Snapchat? . . . A field guide to Millennial dating in New York City” (New York Daily News). When New York–based graphic designers and long-time friends Timothy Goodman and Jessica Walsh found themselves single at the same time, they decided to try an experiment. The old adage says that it takes 40 days to change a habit—could the same be said for love? So they agreed to date each other for 40 days, record their experiences in questionnaires, photographs, videos, texts, and artworks, and post the material on a website they would create for this purpose. What began as a small experiment between two friends became an Internet sensation, drawing 5 million unique (and obsessed) visitors from around the globe to their site and their story. 40 Days of Dating: An Experiment is a beautifully designed, expanded look at the experiment and the results, including a great deal of material that never made it onto the site, such as who they were as friends and individuals before the 40 days and who they have become since.

Polymer Syntheses

Author: Stanley Sandler

Publisher: Elsevier

ISBN: 032315140X

Category: Science

Page: 414

View: 9980

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Polymer Syntheses, Volume II presents detailed laboratory instructions for the preparation of different types of polymers. This book provides information pertinent to useful polymer synthesis. Organized into 10 chapters, this volume begins with an overview of resins derived from urea, melamine, or benzoguanamine. This text then examines the reaction of formaldehyde with hydrogen chloride, which has been shown to lead to the spontaneous production of carcinogen bis(chloromethyl) ether. Other chapters consider the topic of silicone resins or polyorganosiloxanes, as well as the uses of vinyl ether polymers in lacquer resins, adhesives, plasticizers, paints, and copolymer compositions. This book discusses as well the methods of polymerization of acrylic and of methacrylic acid. The final chapter deals with the health and safety aspects of the production of the monomer vinyl chloride. This book is a valuable resource for industrial and polymer chemists. Students of polymer chemistry will also find this book useful.

Chemistry of the Carbonyl Group

A Step-by-Step Approach to Understanding Organic Reaction Mechanisms

Author: Timothy K. Dickens,Stuart Warren

Publisher: John Wiley & Sons

ISBN: 1119459559

Category: Science

Page: 184

View: 907

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Teaches and enables students to build confidence in drawing and manipulating curly arrows, a fundamental skill for all organic chemists This book is an interactive approach to learning about chemistry of the carbonyl group—inviting students to work through its pages with pencil and paper in hand. It educates with the belief that the most effective way to learn is by practice and interaction. With this in mind, the reader is asked to predict what would happen under a specific set of reaction conditions. The book is divided into frames: each frame poses a question and invites the reader to predict what will happen. Subsequent frames give the solution but then pose more questions to develop a theme further. Chemistry of the Carbonyl Group: A Programmed Approach to Organic Reaction Mechanisms, Revised Edition provides a solid grounding in the fundamental reactions of carbonyls. Presented in full colour to enhance the understanding of mechanisms within chemistry, the chapters of this step-by-step guide cover: nucleophilic addition to the carbonyl group; nucleophilic substitution; nucleophilic substitution at the carbonyl group with complete removal of carbonyl oxygen; carbanions and enolisation; and building organic molecules from carbonyl compounds. A must-have book for undergraduate chemists to emphasise understanding in carbonyl group chemistry Goes through all the stages of basic carbonyl chemistry, detailing even the simplest mechanisms A step-by-step learning guide to synthetic chemistry for the first year of a chemistry degree, with all the information needed for independent learning Provides a solid grounding in the fundamental reactions of carbonyls which will inform the understanding of many other organic chemistry reactions Chemistry of the Carbonyl Group: A Programmed Approach to Organic Reaction Mechanisms - Revised Edition is packed with all the information on synthetic chemistry that every first-year student will need in order to learn independently.

Stereochemistry - Workbook

191 Problems and Solutions

Author: Karl-Heinz Hellwich,Carsten Siebert

Publisher: Springer Science & Business Media

ISBN: 9783540329121

Category: Science

Page: 198

View: 5026

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This workbook in stereochemistry is designed for students, lecturers and scientists in chemistry, pharmacy, biology and medicine who deal with chiral chemical compounds and their properties. It serves as a supplement to textbooks and seminars and thus provides selected examples for students to practice the use of the conventions and terminology for the exact three-dimensional description of chemical compounds. It contains 191 problems with extended solutions.

Managing Natural Resources for Development in Africa

A Resource Book

Author: Washington Odongo Ochola,P. C. Sanginga,Isaac Bekalo

Publisher: IDRC

ISBN: 9966792090

Category: Business & Economics

Page: 538

View: 2739

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The complex and dynamic interlinks between natural resource management (NRM) and development have long been recognized by national and international research and development organizations and have generated voluminous literature. However, much of what is available in the form of university course books, practical learning manuals and reference materials in NRM is based on experiences from outside Africa. Managing Natural Resources for Development in Africa: A Resource Book provides an understanding of the various levels at which NRM issues occur and are being addressed scientifically, economically, socially and politically. The book's nine chapters present state-of-the-art perspectives within a holistic African context. The book systematically navigates the tricky landscape of integrated NRM, with special reference to Eastern and Southern Africa, against the backdrop of prevailing local, national, regional and global social, economic and environmental challenges. The authors' wide experience, the rich references made to emerging challenges and opportunities, and the presentation of different tools, principles, approaches, case studies and processes make the book a rich and valuable one-stop resource for postgraduate students, researchers, policymakers and NRM practitioners. The book is designed to help the reader grasp in-depth NRM perspectives and presents innovative guidance for research design and problem solving, including review questions, learning activities and recommended further reading. The book was developed through a writeshop process by a multi-disciplinary team of lecturers from the University of Nairobi, Egerton University, Kenyatta University, the University of Zimbabwe, the University of Malawi, Makerere University and the University of Dar es Salam. In addition, selected NRM experts from regional and international research organizations including the World Agroforestry Center (ICRAF), the Africa Forest Forum, RUFORUM, IIRR and the International Development Research Centre (IDRC) participated in the writeshop and contributed material to the book.

Frontier orbitals and organic chemical reactions

Author: Ian Fleming

Publisher: John Wiley & Sons

ISBN: N.A

Category: Science

Page: 249

View: 7881

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Provides a basic introduction to frontier orbital theory with a review of its applications in organic chemistry. Assuming the reader is familiar with the concept of molecular orbital as a linear combination of atomic orbitals the book is presented in a simple style, without mathematics making it accessible to readers of all levels.

86 Tricks to Ace Organic Chemistry

Author: AceOrganicChem.com

Publisher: CreateSpace

ISBN: 9781449529482

Category: Science

Page: 166

View: 3921

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Explains the basic principles of organic chemistry and provides help with reactions, synthesis, mechanisms, spectra, reagents, and study methods.

Asymmetric Synthesis of Natural Products

Author: Ari M. P. Koskinen

Publisher: John Wiley & Sons

ISBN: 1118347331

Category: Science

Page: 328

View: 8548

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Asymmetric Synthesis of Natural Products, 2nd Edition introduces students to this rapidly growing field of organic chemistry. The initial chapters present the foundations of asymmetric synthesis, including the theory and applications of individual asymmetric reactions. This is followed by chapters on each of the major individual classes of natural products; their structures, biosynthesis and interrelationships as well as examples of asymmetric syntheses and the practical value of these compounds. Natural product classes covered include carbohydrates, amino acids, peptides, proteins, nucleosides, nucleotides, nucleic acids, polyketides, isoprenoids, shikamic acid derivatives and alkaloids. For this second edition the text has been thoroughly updated and expanded, and includes new discussions and examples covering atom and redox economies, practical aspects and environmental awareness. Organocatalysis has emerged completely in the last ten years, and has been fully integrated into this new edition.

Organic Chemistry I For Dummies

Author: Arthur Winter

Publisher: John Wiley & Sons

ISBN: 1119296579

Category: Science

Page: 384

View: 6571

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Organic Chemistry I For Dummies, 2nd Edition (9781119293378) was previously published as Organic Chemistry I For Dummies, 2nd Edition (9781118828076). While this version features a new Dummies cover and design, the content is the same as the prior release and should not be considered a new or updated product. The easy way to take the confusion out of organic chemistry Organic chemistry has a long-standing reputation as a difficult course. Organic Chemistry I For Dummies takes a simple approach to the topic, allowing you to grasp concepts at your own pace. This fun, easy-to-understand guide explains the basic principles of organic chemistry in simple terms, providing insight into the language of organic chemists, the major classes of compounds, and top trouble spots. You'll also get the nuts and bolts of tackling organic chemistry problems, from knowing where to start to spotting sneaky tricks that professors like to incorporate. Refreshed example equations New explanations and practical examples that reflect today's teaching methods Fully worked-out organic chemistry problems Baffled by benzines? Confused by carboxylic acids? Here's the help you need—in plain English!